Randomized clinical trials

Equipoise abandoned? Randomization and clinical trials

Equipoise abandoned? Randomization and clinical trials

Randomized, clinical trials are the strongest method we have to define the efficacy of new drugs. Recently, however, novel agents that show remarkable responses with minimal toxicity in patients with advanced cancer have been discovered [1], and these present a challenge for the ethical conduct of randomized trials...

Fool’s gold, lost treasures, and the randomized clinical trial

Fool’s gold, lost treasures, and the randomized clinical trial

Randomized controlled trials with a survival endpoint are the gold standard for clinical research, but have failed to achieve cures for most advanced malignancies. The high costs of randomized clinical trials slow progress (thereby causing avoidable loss of life) and increase health care costs...